M-CSF

Ligand id: 4905

Name: M-CSF

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Synonyms
CSF-1 | lanimostim | macrophage-CSF
Comments
CSF1 controls survival and differentiation of macrophages via activation of the CSF1 receptor (a receptor tyrosine kinase). The biologically active peptide is a homodimer or a heterodimer.
Pharmacological modulators of the CSF1/CSF1R axis, targeting tumour-associated macrophage (TAM) survival, are being developed for various solid tumour and hematological oncology indications as well as for autoimmune diseases.
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
CSF1 colony stimulating factor 1 Human prepro-macrophage colony stimulating factor 1 colony stimulating factor 1 (macrophage), MCSF, M-CSF, MGC31930
Database Links
GtoPdb PubChem SID 178101604
UniProtKB P09603 (Hs)
Wikipedia CSF1