M-CSF

Home
Ligands
M-CSF (Human)

Ligand id: 4905

Name: M-CSF

Species: Human

Summary
Biological activity
References
Structure
Similar ligands
Immunopharmacology

Classification
Compound class	Endogenous peptide in human, mouse or rat

Gene/Precursor

Gene symbol	Gene name	Species	Precursor protein name	Synonyms
CSF1	colony stimulating factor 1	Human	prepro-macrophage colony stimulating factor 1	colony stimulating factor 1 (macrophage), MCSF, M-CSF, MGC31930

Synonyms
CSF-1
lanimostim
macrophage-CSF

Synonyms

CSF-1

lanimostim

macrophage-CSF

Database Links
UniProtKB	P09603 (Hs)
Wikipedia	CSF1

Comments
CSF1 controls survival and differentiation of macrophages via activation of the CSF1 receptor (a receptor tyrosine kinase). The biologically active peptide is a homodimer or a heterodimer. Pharmacological modulators of the CSF1/CSF1R axis, targeting tumour-associated macrophage (TAM) survival, are being developed for various solid tumour and hematological oncology indications as well as for autoimmune diseases.

Comments

CSF1 controls survival and differentiation of macrophages via activation of the CSF1 receptor (a receptor tyrosine kinase). The biologically active peptide is a homodimer or a heterodimer.
Pharmacological modulators of the CSF1/CSF1R axis, targeting tumour-associated macrophage (TAM) survival, are being developed for various solid tumour and hematological oncology indications as well as for autoimmune diseases.