M-CSF

Ligand id: 4905

Name: M-CSF

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
CSF1 colony stimulating factor 1 Human prepro-macrophage colony stimulating factor 1 colony stimulating factor 1 (macrophage), MCSF, M-CSF, MGC31930
Synonyms
CSF-1
lanimostim
macrophage-CSF
Database Links
UniProtKB P09603 (Hs)
Wikipedia CSF1
Comments
CSF1 controls survival and differentiation of macrophages via activation of the CSF1 receptor (a receptor tyrosine kinase). The biologically active peptide is a homodimer or a heterodimer.
Pharmacological modulators of the CSF1/CSF1R axis, targeting tumour-associated macrophage (TAM) survival, are being developed for various solid tumour and hematological oncology indications as well as for autoimmune diseases.