tamatinib

Ligand id: 5706

Name: tamatinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 128.75
Molecular weight 470.17
XLogP 1.98
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Prodrug fostamatinib
IUPAC Name
6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[2,3-e][1,4]oxazin-3-one
Synonyms
R 406 | R-406 | R406 free base
Database Links
CAS Registry No. 841290-80-0
ChEMBL Ligand CHEMBL475251
PubChem CID 11213558
RCSB PDB Ligand 585
Search Google for chemical match using the InChIKey NHHQJBCNYHBUSI-UHFFFAOYSA-N
Search Google for chemicals with the same backbone NHHQJBCNYHBUSI
Search UniChem for chemical match using the InChIKey NHHQJBCNYHBUSI-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone NHHQJBCNYHBUSI
SynPHARM 79688 (in complex with spleen associated tyrosine kinase)
81294 (in complex with spleen associated tyrosine kinase)
Comments
Tamatinib (R406) is a potent ATP-competitive (Type I) Syk inhibitor. It is the active form of the prodrug fostamatinib.