tamatinib

Ligand id: 5706

Name: tamatinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 128.75
Molecular weight 470.17
XLogP 1.98
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Prodrug fostamatinib
IUPAC Name
6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[2,3-e][1,4]oxazin-3-one
Synonyms
R 406 | R-406 | R406 free base
Comments
Tamatinib (R406) is a potent ATP-competitive (Type I) Syk inhibitor. It is the active form of the prodrug fostamatinib.
Database Links
CAS Registry No. 841290-80-0
ChEMBL Ligand CHEMBL475251
GtoPdb PubChem SID 178102333
PubChem CID 11213558
RCSB PDB Ligand 585
Search Google for chemical match using the InChIKey NHHQJBCNYHBUSI-UHFFFAOYSA-N
Search Google for chemicals with the same backbone NHHQJBCNYHBUSI
Search UniChem for chemical match using the InChIKey NHHQJBCNYHBUSI-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone NHHQJBCNYHBUSI
SynPHARM 79688 (in complex with spleen associated tyrosine kinase)
81294 (in complex with spleen associated tyrosine kinase)
85059 (in complex with spleen associated tyrosine kinase)