fostamatinib

Ligand id: 7796

Name: fostamatinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 4
Rotatable bonds 10
Topological polar surface area 196.53
Molecular weight 580.15
XLogP 0.32
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Is prodrug? Yes
Active form tamatinib
IUPAC Name
[6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[2,3-e][1,4]oxazin-4-yl]methyl dihydrogen phosphate
International Nonproprietary Names
INN number INN
9022 fostamatinib
Synonyms
R 788 | R-788 | R7935788
Database Links
CAS Registry No. 901119-35-5
ChEMBL Ligand CHEMBL2103830
PubChem CID 11671467
RCSB PDB Ligand 2RC
Search Google for chemical match using the InChIKey GKDRMWXFWHEQQT-UHFFFAOYSA-N
Search Google for chemicals with the same backbone GKDRMWXFWHEQQT
Search PubMed clinical trials fostamatinib
Search PubMed titles fostamatinib
Search PubMed titles/abstracts fostamatinib
Search UniChem for chemical match using the InChIKey GKDRMWXFWHEQQT-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone GKDRMWXFWHEQQT
Wikipedia Fostamatinib
Comments
Fostamatinib was an investigational spleen tyrosine kinase (Syk) inhibitor, although development in rheumatoid arthritis was discontinued in 2013 due to a lack of observed efficacy. The compound is administered orally as a disodium salt (PubChem CID 25008120) and this prodrug is rapidly converted to tamatinib by alkaline phosphatases in intestinal enterocytes [2].