IL-33

Ligand id: 5880

Name: IL-33

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Interleukins
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
IL33 interleukin 33 Human prepro-interleukin-33 C9orf26, chromosome 9 open reading frame 26 (NF-HEV), DKFZp586H0523, DVS27, DVS27-related protein, IL1F11, interleukin-1 family, member 11, NF-HEV, nuclear factor for high endothelial venules
Synonyms
IL-1F11
Database Links
Ensembl Gene ENSG00000137033 (Hs)
Human Protein Atlas ENSG00000137033 (Hs)
UniProtKB O95760 (Hs)
Wikipedia Il-33
Comments
IL-33 is an IL-1 family cytokine. Its main cellular targets are innate lymphoid cells type 2 (ILC2), involved in the initiation of the type 2 immune response (secretion of IL-5 and IL-13) during parasitic infection and allergic diseases such as asthma. Full length IL-33 is cleaved by mast cell chymase (chymase 1; CMA1) to produce its significantly more active form [3].

The ST2/IL-33 axis is recognized as playing an important role in the development/exacerbation of IgE-dependent inflammations such as asthma and atopic dermatitis [1-2], and is therefore receiving much interest from the pharmaceutical industry. Blockade of IL-33 activity (and/or its receptor ST2) represent potential novel mechanisms for pharmaceutical intervention to suppress allergy and mast cell-eosinophil interplay. Indeed, mAb AMG-282 is a fully human anti-IL-33 monoclonal antibody, in Phase 1 development as a potential therapy for mild atopic asthma and chronic rhinosinusitis.