triciribine

Ligand id: 5920

Name: triciribine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 129.89
Molecular weight 320.12
XLogP -1.95
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-{5-amino-7-methyl-2,6,7,9,11-pentaazatricyclo[6.3.1.0^{4,12}]dodeca-1(12),3,5,8,10-pentaen-2-yl}-5-(hydroxymethyl)oxolane-3,4-diol
International Nonproprietary Names
INN number INN
5115 triciribine
Synonyms
Akt inhibitor V | Akt/protein kinase B signaling inhibitor-2 | API-2 | NSC-154020 | tricyclic nucleoside (TCN)
Database Links
CAS Registry No. 35943-35-2
ChEMBL Ligand CHEMBL1892348
PubChem CID 290486
Search Google for chemical match using the InChIKey HOGVTUZUJGHKPL-UHFFFAOYSA-N
Search Google for chemicals with the same backbone HOGVTUZUJGHKPL
Search PubMed clinical trials triciribine
Search PubMed titles triciribine
Search PubMed titles/abstracts triciribine
Search UniChem for chemical match using the InChIKey HOGVTUZUJGHKPL-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone HOGVTUZUJGHKPL
Comments
The ligand image above represents this compound as used in the screens listed, and does not specify stereochemistry. The INN-assigned compound triciribine does have defined stereocentres and is represented by CID 65399.
Triciribine is an inhibitor of Akt signalling [3], HIV-1/2 [4], DNA synthesis [5] and exhibits in vitro and in vivo antitumour effects [6].