donepezil

Ligand id: 6599

Name: donepezil

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 38.77
Molecular weight 379.21
XLogP 4.8
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1996))
IUPAC Name
5,6-dimethoxy-2-[[1-(phenylmethyl)piperidin-4-yl]methyl]-2,3-dihydroinden-1-one
International Nonproprietary Names
INN number INN
7517 donepezil
Synonyms
Aricept® | E-2020
Database Links
CAS Registry No. 120014-06-4
ChEMBL Ligand CHEMBL502
DrugBank Ligand DB00843
PubChem CID 3152
Search Google for chemical match using the InChIKey ADEBPBSSDYVVLD-UHFFFAOYSA-N
Search Google for chemicals with the same backbone ADEBPBSSDYVVLD
Search PubMed clinical trials donepezil
Search PubMed titles donepezil
Search PubMed titles/abstracts donepezil
Search UniChem for chemical match using the InChIKey ADEBPBSSDYVVLD-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone ADEBPBSSDYVVLD
SynPHARM 78555 (in complex with acetylcholinesterase (Cartwright blood group))
Wikipedia Donepezil
Comments
May be refered to as donepezil hydrochloride (PubChem CID 5741). In addition to the original brand, Aricept, generic donepezil formulations are now approved by the US FDA.