Ligand id: 6599

Name: donepezil

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 38.77
Molecular weight 379.21
XLogP 4.8
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Donepezil provides modest benefits in cognition and/or behavior in Alzheimer's disease sufferers [4]. Donepezil has also been studied in patients with other conditions involving cognitive deficit (eg schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, and Down's syndrome).
Donepezil is a component of the approved AD fixed-dose medication Namzaric® (which contains donepezil plus memantine).
Mechanism Of Action and Pharmacodynamic Effects
Donepezil is an acetylcholinesterase inhibitor which causes increased cortical acetylcholine, effecting increased levels of acetylcholine at cholinergic synapses.