Structure and Physico-chemical Properties
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Molecular properties generated using the CDK |
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Classification  |
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| Compound class | Synthetic organic |
| IUPAC Name |
| N-(2-diethylaminoethyl)-2-[2-[(4-fluorophenyl)methylsulfanyl]-4-oxo-6,7-dihydro-5H-cyclopenta[e]pyrimidin-1-yl]-N-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]acetamide |
| International Nonproprietary Names |
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| INN number | INN |
| 8703 | darapladib |
| Synonyms |
| SB 480848 | SB-480848 |
| Comments |
| Darapladib is a potent PLA2G7 (commonly referred to as Lp-PLA2) inhibitor. Darapladib and analogues such as rilapladib are clinical drug candidates with potential to reduce the risk of atherosclerosis and associated clinical sequelae [10]. |
| Database Links |
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| CAS Registry No. | 356057-34-6 (source: PubChem) |
| ChEMBL Ligand | CHEMBL204021 |
| GtoPdb PubChem SID | 178103307 |
| PubChem CID | 9939609 |
| RCSB PDB Ligand | 5HV |
| Search Google for chemical match using the InChIKey | WDPFJWLDPVQCAJ-UHFFFAOYSA-N |
| Search Google for chemicals with the same backbone | WDPFJWLDPVQCAJ |
| Search PubMed clinical trials | darapladib |
| Search PubMed titles | darapladib |
| Search PubMed titles/abstracts | darapladib |
| Search UniChem for chemical match using the InChIKey | WDPFJWLDPVQCAJ-UHFFFAOYSA-N |
| Search UniChem for chemicals with the same backbone | WDPFJWLDPVQCAJ |
| SynPHARM |
78680 (in complex with PLA2-G7) 84827 (in complex with PLA2-G7) 84828 (in complex with PLA2-G7) |
| Wikipedia | Darapladib |
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Sponsored products disclaimer
Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.
Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please contact us.
✖
Darapladib
Cat. No. 6755 |
