Classification
Compound class	Synthetic organic

IUPAC Name

N-(2-diethylaminoethyl)-2-[2-[(4-fluorophenyl)methylsulfanyl]-4-oxo-6,7-dihydro-5H-cyclopenta[e]pyrimidin-1-yl]-N-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]acetamide

International Nonproprietary Names
INN number	INN
8703	darapladib

Synonyms

SB 480848 | SB-480848

Comments

Darapladib is a potent PLA2G7 (commonly referred to as Lp-PLA2) inhibitor. Darapladib and analogues such as rilapladib are clinical drug candidates with potential to reduce the risk of atherosclerosis and associated clinical sequelae [10].

Database Links
CAS Registry No.	356057-34-6 (source: PubChem)
ChEMBL Ligand	CHEMBL204021
GtoPdb PubChem SID	178103307
PubChem CID	9939609
RCSB PDB Ligand	5HV
Search Google for chemical match using the InChIKey	WDPFJWLDPVQCAJ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone	WDPFJWLDPVQCAJ
Search PubMed clinical trials	darapladib
Search PubMed titles	darapladib
Search PubMed titles/abstracts	darapladib
Search UniChem for chemical match using the InChIKey	WDPFJWLDPVQCAJ-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone	WDPFJWLDPVQCAJ
SynPHARM	78680 (in complex with PLA2-G7) 84827 (in complex with PLA2-G7) 84828 (in complex with PLA2-G7)
Wikipedia	Darapladib