rilapladib

Ligand id: 7376

Name: rilapladib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 14
Topological polar surface area 78.39
Molecular weight 735.26
XLogP 11.03
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-[2-[(2,3-difluorophenyl)methylsulfanyl]-4-oxoquinolin-1-yl]-N-[1-(2-methoxyethyl)piperidin-4-yl]-N-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]acetamide
International Nonproprietary Names
INN number INN
8704 rilapladib
Synonyms
SB 659032
Database Links
CAS Registry No. 412950-08-4 (source: PubChem)
ChEMBL Ligand CHEMBL2104981
PubChem CID 9918381
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Comments
Lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitors such as darapladib and rilapladib are in clinical development to determine their effects on reducing the risk of atherosclerosis and associated clinical sequelae [3].