glimepiride

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Ligands
glimepiride

Ligand id: 6820

Name: glimepiride

Structure and Physico-chemical Properties

2D Structure

Calculated Physico-chemical Properties
Hydrogen bond acceptors	9
Hydrogen bond donors	3
Rotatable bonds	11
Topological polar surface area	133.06
Molecular weight	490.22
XLogP	4.18
No. Lipinski's rules broken	1

Molecular properties generated using the CDK

Classification
Compound class	Synthetic organic
Approved drug?	Yes (source: FDA (1995))

IUPAC Name
3-ethyl-4-methyl-2-oxo-N-(2-{4-[({[(1r,4r)-4-methylcyclohexyl]carbamoyl}amino)sulfonyl]phenyl}ethyl)-2,5-dihydro-1H-pyrrole-1-carboxamide

IUPAC Name

3-ethyl-4-methyl-2-oxo-N-(2-{4-[({[(1r,4r)-4-methylcyclohexyl]carbamoyl}amino)sulfonyl]phenyl}ethyl)-2,5-dihydro-1H-pyrrole-1-carboxamide

International Nonproprietary Names
INN number	INN
5718	glimepiride

Synonyms
Amaryl®
glimepride
HOE-490
Sugral®

Synonyms

Amaryl®

glimepride

HOE-490

Sugral®

Database Links
CAS Registry No.	93479-97-1
ChEMBL Ligand	CHEMBL1481
DrugBank Ligand	DB00222
PubChem CID	3476
Search Google for chemical match using the InChIKey	WIGIZIANZCJQQY-RUCARUNLSA-N
Search Google for chemicals with the same backbone	WIGIZIANZCJQQY
Search PubMed clinical trials	glimepiride
Search PubMed titles	glimepiride
Search PubMed titles/abstracts	glimepiride
Wikipedia	Glimepiride

Comments
Only approved by the EMA (2007) to be used in combination with pioglitazone (Tandemact®). Note that the PubChem CID listed above refers to the non-isomeric molecule. We show the isomeric form which corresponds to the structure held with the INN record for this compound.

Comments

Only approved by the EMA (2007) to be used in combination with pioglitazone (Tandemact®). Note that the PubChem CID listed above refers to the non-isomeric molecule. We show the isomeric form which corresponds to the structure held with the INN record for this compound.