Classification
Compound class	Synthetic organic
Approved drug?	Yes (source: FDA (1996))
Is prodrug?	Yes
Active form	SN-38

International Nonproprietary Names
INN number	INN
6694	irinotecan

Synonyms

(+)-irinotecan

biotecan

Campto®

Camptosar®

CPT-11

irinotecan hydrochloride

Database Links
CAS Registry No.	97682-44-5
ChEMBL Ligand	CHEMBL481
DrugBank Ligand	DB00762
PubChem CID	60838
RCSB PDB Ligand	CP0
Search Google for chemical match using the InChIKey	UWKQSNNFCGGAFS-XIFFEERXSA-N
Search Google for chemicals with the same backbone	UWKQSNNFCGGAFS
Search PubMed clinical trials	irinotecan
Search PubMed titles	irinotecan
Search PubMed titles/abstracts	irinotecan
Wikipedia	Irinotecan

Comments

A semisynthetic analogue of the natural alkaloid camptothecin (PubChem CID 24360) which functions as a DNA replication inhibitor by binding to topoisomerase I/DNA complexes [5]. Camptothecin was first isolated from the bark and stem of Camptotheca acuminata, the Chinsese happy tree. The PubChem CID linked here is the same isomer as recorded in irinotecan's INN record.