Ligand id: 6823

Name: irinotecan

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 112.51
Molecular weight 586.28
XLogP 4.12
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
A topoisomerase inhibitor used for the treatment of cancer: colon cancer, especially in combination with other chemotherapy agents.
Mechanism Of Action and Pharmacodynamic Effects
Irinotecan has the same molecular mechanism of action as its parent molecule camptothecin, i.e. it interferes with DNA replication by binding to DNA topoisomerase I/DNA complexes. This action leads to DNA damage and apoptosis.