buclizine

Ligand id: 7134

Name: buclizine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 6.48
Molecular weight 432.23
XLogP 9.94
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes
IUPAC Name
1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)(phenyl)methyl]piperazine
International Nonproprietary Names
INN number INN
291 buclizine
Synonyms
UCB-4445
Database Links
CAS Registry No. 82-95-1
ChEMBL Ligand CHEMBL1201271
DrugBank Ligand DB00354
PubChem CID 6729
Search Google for chemical match using the InChIKey MOYGZHXDRJNJEP-UHFFFAOYSA-N
Search Google for chemicals with the same backbone MOYGZHXDRJNJEP
Search PubMed clinical trials buclizine
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Wikipedia Buclizine
Comments
Buclizine is a piperazine derivative antihistamine and anticholinergic drug, with antiemetic properties.