buclizine

Ligand id: 7134

Name: buclizine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 6.48
Molecular weight 432.23
XLogP 9.94
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Mainly used for its antiemetic and antivertigo actions. There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation. The Electronic Medicines Compendium (eMC) lists buclizine only as an active ingredient in a multi-component anti-migraine treatment (Migraleve&re;) alongside paracetamol and codeine.
Mechanism Of Action and Pharmacodynamic Effects
Buclizine has various and complex actions likely involving inhibition of muscarinic cholinergic and histaminic synapses within the chemotrigger zone (CTZ) of the medulla, and this controls vomiting.
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