ifosfamide

Ligand id: 7201

Name: ifosfamide

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 51.38
Molecular weight 260.02
XLogP 0.84
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1988))
IUPAC Name
3-(2-chloroethyl)-2-[(2-chloroethyl)amino]-1,3,2λ5-oxazaphosphinan-2-one
International Nonproprietary Names
INN number INN
2865 ifosfamide
Synonyms
Holoxan® | Ifex® | MJF-9325 | Z-4942
Database Links
CAS Registry No. 3778-73-2
ChEMBL Ligand CHEMBL1024
DrugBank Ligand DB01181
GtoPdb PubChem SID 178103776
PubChem CID 3690
Search Google for chemical match using the InChIKey HOMGKSMUEGBAAB-UHFFFAOYSA-N
Search Google for chemicals with the same backbone HOMGKSMUEGBAAB
Search PubMed clinical trials ifosfamide
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Search PubMed titles/abstracts ifosfamide
Search UniChem for chemical match using the InChIKey HOMGKSMUEGBAAB-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone HOMGKSMUEGBAAB
Wikipedia Ifosfamide
Comments
Ifosfamide is a DNA alkylating drug, and has additional immunosuppressant action. Ifosfamide is biologically inactive. In vivo metabolism is necessary to generate the active substance, isophosphamide mustard (IPM; PubChem CID 100427) [1].