ifosfamide

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Ligands
ifosfamide

Ligand id: 7201

Name: ifosfamide

Structure and Physico-chemical Properties

2D Structure

Calculated Physico-chemical Properties
Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	5
Topological polar surface area	51.38
Molecular weight	260.02
XLogP	0.84
No. Lipinski's rules broken	0

Molecular properties generated using the CDK

Classification
Compound class	Synthetic organic
Approved drug?	Yes (source: FDA (1988))

IUPAC Name
3-(2-chloroethyl)-2-[(2-chloroethyl)amino]-1,3,2λ⁵-oxazaphosphinan-2-one

IUPAC Name

3-(2-chloroethyl)-2-[(2-chloroethyl)amino]-1,3,2λ⁵-oxazaphosphinan-2-one

International Nonproprietary Names
INN number	INN
2865	ifosfamide

Synonyms
Holoxan®
Ifex®
MJF-9325
Z-4942

Synonyms

Holoxan®

Ifex®

MJF-9325

Z-4942

Database Links
CAS Registry No.	3778-73-2
ChEMBL Ligand	CHEMBL1024
DrugBank Ligand	DB01181
PubChem CID	3690
Search Google for chemical match using the InChIKey	HOMGKSMUEGBAAB-UHFFFAOYSA-N
Search Google for chemicals with the same backbone	HOMGKSMUEGBAAB
Search PubMed clinical trials	ifosfamide
Search PubMed titles	ifosfamide
Search PubMed titles/abstracts	ifosfamide
Wikipedia	Ifosfamide

Comments
Ifosfamide is a DNA alkylating drug, and has additional immunosuppressant action. Ifosfamide is biologically inactive. In vivo metabolism is necessary to generate the active substance, isophosphamide mustard (IPM; PubChem CID 100427) [1].

Comments

Ifosfamide is a DNA alkylating drug, and has additional immunosuppressant action. Ifosfamide is biologically inactive. In vivo metabolism is necessary to generate the active substance, isophosphamide mustard (IPM; PubChem CID 100427) [1].