lomitapide

Ligand id: 7439

Name: lomitapide

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 14
Topological polar surface area 61.44
Molecular weight 693.28
XLogP 13.87
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (2012), EMA (2013))
IUPAC Name
N-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide
International Nonproprietary Names
INN number INN
9120 lomitapide
Synonyms
AEGR-733 | BMS-201038 | Juxtapid® | Lojuxta®
Database Links
CAS Registry No. 82431-12-5
ChEBI CHEBI:72297
ChEMBL Ligand CHEMBL354541
DrugBank Ligand DB08827
GtoPdb PubChem SID 178104011
PubChem CID 9853053
Search Google for chemical match using the InChIKey MBBCVAKAJPKAKM-UHFFFAOYSA-N
Search Google for chemicals with the same backbone MBBCVAKAJPKAKM
Search PubMed clinical trials lomitapide
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Search UniChem for chemical match using the InChIKey MBBCVAKAJPKAKM-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone MBBCVAKAJPKAKM
Wikipedia Lomitapide
Comments
Lomitapide is a lipid-lowering agent for the treatment of familial hypercholesterolemia.