estradiol valerate

Ligand id: 7655

Name: estradiol valerate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 46.53
Molecular weight 356.24
XLogP 6.78
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1954))
Is prodrug? Yes
Active form 17β-estradiol
IUPAC Name
[(8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] pentanoate
International Nonproprietary Names
INN number INN
3921 estradiol valerate
Synonyms
Climaval®
Database Links
CAS Registry No. 979-32-8
ChEMBL Ligand CHEMBL1511
GtoPdb PubChem SID 223365990
PubChem CID 13791
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Wikipedia Estradiol valerate
Comments
Estradiol valerate is a synthetic ester of the endogenous estrogen, 17β-estradiol. This ester is absorbed more slowly and has a longer duration of action than the native hormone. Estradiol valerate is cleaved in vivo by plasma and liver esterases to form 17β-estradiol and valeric acid.