estradiol valerate

Ligand id: 7655

Name: estradiol valerate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 46.53
Molecular weight 356.24
XLogP 6.78
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Several brands of combined oral contraceptives (Natazia®, Qlaira® and Delestrogen® for example) contain estradiol valerate and dienogest. Such drug combinations are covered by PubChem CID 9874560. In the UK, estradiol valerate is used as hormone replacement therapy (HRT) for oestrogen deficiency symptoms in postmenopausal women who have been hysterectomised.
Mechanism Of Action and Pharmacodynamic Effects
COCs reduce the risk of pregnancy by primarily by supressing ovulation, but also effect changes which render the cervix and endometrium hostile to sperm.
External links