lesinurad

Ligand id: 7673

Name: lesinurad

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 93.31
Molecular weight 403
XLogP 6.16
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (2015), EMA (2016))
IUPAC Name
2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid
International Nonproprietary Names
INN number INN
9345 lesinurad
Synonyms
RDEA-594 | RDEA594 | Zurampic®
Database Links
CAS Registry No. 878672-00-5 (source: SciFinder)
ChEMBL Ligand CHEMBL2105720
GtoPdb PubChem SID 223366008
PubChem CID 53465279
Search Google for chemical match using the InChIKey FGQFOYHRJSUHMR-UHFFFAOYSA-N
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Search UniChem for chemical match using the InChIKey FGQFOYHRJSUHMR-UHFFFAOYSA-N
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Comments
Lesinurad is an orally available inhibitor of URAT1, the renal transporter that regulates uric acid excretion from the body [1-2].