Ligand id: 7673

Name: lesinurad

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 93.31
Molecular weight 403
XLogP 6.16
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Burns CM, Wortmann RL. (2011)
Gout therapeutics: new drugs for an old disease.
Lancet, 377 (9760): 165-77. [PMID:20719377]
2. Yeh L, Shen Z and Kerr B. (2009)
RDEA594: a potent URAT1 inhibitor without affecting other important renal transporters, OAT1 and OAT 3 [abstract].
Ann Rheum Dis, 68: A320.