AZD5672

Ligand id: 7686

Name: AZD5672

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 0
Rotatable bonds 12
Topological polar surface area 111.83
Molecular weight 639.26
XLogP 4.89
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[1-[(3R)-3-(3,5-difluorophenyl)-3-(1-methylsulfonylpiperidin-4-yl)propyl]piperidin-4-yl]-N-ethyl-2-(4-methylsulfonylphenyl)acetamide
Synonyms
AZD 5672 | AZD-5672
Database Links
ChEMBL Ligand CHEMBL1951914
PubChem CID 11614352
Search Google for chemical match using the InChIKey QOSMEMHKXNNIGG-SSEXGKCCSA-N
Search Google for chemicals with the same backbone QOSMEMHKXNNIGG
Search UniChem for chemical match using the InChIKey QOSMEMHKXNNIGG-SSEXGKCCSA-N
Search UniChem for chemicals with the same backbone QOSMEMHKXNNIGG
Comments
AZD5672 was an investigational small molecule antagonist of the C-C chemokine receptor type 5 (CCR5) expressed on T cells. AZD5672-induced CCR5 blockade was investigated for action in treating rheumatoid arthritis, but with discouraging clinical trial results. Other CCR5 antagonists (ancriviroc and maraviroc) have also proven ineffective in RA clinical trials [4]

The structure shown here was drawn from [1].