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Molecular properties generated using the CDK |
Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-[6-[4-(4-ethylpiperazin-1-yl)anilino]pyrimidin-4-yl]-1-methylurea |
Synonyms ![]() |
BGJ 398 | BGJ398 | NVP-BGJ398 |
Database Links ![]() |
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CAS Registry No. | 872511-34-7 |
ChEMBL Ligand | CHEMBL1852688 |
GtoPdb PubChem SID | 223366206 |
PubChem CID | 53235510 |
RCSB PDB Ligand | 07J |
Search Google for chemical match using the InChIKey | QADPYRIHXKWUSV-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | QADPYRIHXKWUSV |
Search UniChem for chemical match using the InChIKey | QADPYRIHXKWUSV-UHFFFAOYSA-N |
Search UniChem for chemicals with the same backbone | QADPYRIHXKWUSV |
SynPHARM | 80719 (in complex with fibroblast growth factor receptor 1) |
Comments |
The discovery and synthesis of BGJ-398 is described in [1], where it is compound 1h. It is an orally bioavailable pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities [1]. |