inebilizumab

Ligand id: 7992

Name: inebilizumab

Classification
Compound class Antibody
International Nonproprietary Names
INN number INN
9985 inebilizumab
Synonyms
Names References
HB12 6
MEDI 551
MEDI-551
MEDI551
Database Links
Specialist databases
IMGT/mAb-DB 553
Other databases
Search PubMed clinical trials inebilizumab
Search PubMed titles inebilizumab
Search PubMed titles/abstracts inebilizumab
Comments
Inebilizumab is an investigational humanized monoclonal antibody (mAb) directed against CD19, a cell-surface antigen expressed on cells of B cell lineage. Inebilizumab has potential immunomodulating and antineoplastic activities. Tested preclinically as a mouse anti-CD19 mAb (clone HB12; [6]), the mAb was initailly humanized (by Cellective Therapeutics, Inc., a spinout company from Duke University where the antibody began its life) prior to being acquired by MedImmune (now part of Astra Zeneca) for commercial development.

Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record. A protein BLAST search of patented sequences reveals 100% matches between the heavy and light variable sequences of inebilizumab and sequences 106 and 111 respectively, in patent US8323653 B2 [1]. A detailed peptide sequence analysis suggests that inebilizumab is likely to be clone 16C4 in this patent.