flibanserin

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Ligands
flibanserin

Ligand id: 8182

Name: flibanserin

Structure and Physico-chemical Properties

2D Structure

Calculated Physico-chemical Properties
Hydrogen bond acceptors	5
Hydrogen bond donors	1
Rotatable bonds	5
Topological polar surface area	38.82
Molecular weight	390.17
XLogP	4.3
No. Lipinski's rules broken	0

Molecular properties generated using the CDK

Classification
Compound class	Synthetic organic
Approved drug?	Yes (source: FDA (2015))

IUPAC Name
3-[2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazol-2-one

IUPAC Name

3-[2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazol-2-one

International Nonproprietary Names
INN number	INN
7512	flibanserin

Synonyms
Addyi®
BIMT-17
Girosa® (proposed trade name)

Synonyms

Addyi®

BIMT-17

Girosa® (proposed trade name)

Database Links
CAS Registry No.	167933-07-5
ChEMBL Ligand	CHEMBL231068
DrugBank Ligand	DB04908
PubChem CID	6918248
Search Google for chemical match using the InChIKey	PPRRDFIXUUSXRA-UHFFFAOYSA-N
Search Google for chemicals with the same backbone	PPRRDFIXUUSXRA
Search PubMed clinical trials	flibanserin
Search PubMed titles	flibanserin
Search PubMed titles/abstracts	flibanserin
Wikipedia	Flibanserin

Comments
Flibanserin is reported as a serotonin 5-HT_1A agonist and 5-HT_2A antagonist [2]. The compound was originally investigated as a antidepressant [3-4].

Comments

Flibanserin is reported as a serotonin 5-HT_1A agonist and 5-HT_2A antagonist [2]. The compound was originally investigated as a antidepressant [3-4].