Ligand id: 8182

Name: flibanserin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 38.82
Molecular weight 390.17
XLogP 4.3
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Allers KA, Dremencov E, Ceci A, Flik G, Ferger B, Cremers TI, Ittrich C, Sommer B. (2010)
Acute and repeated flibanserin administration in female rats modulates monoamines differentially across brain areas: a microdialysis study.
J Sex Med, 7 (5): 1757-67. [PMID:20163532]
2. Borsini F, Evans K, Jason K, Rohde F, Alexander B, Pollentier S. (2002)
Pharmacology of flibanserin.
CNS Drug Rev, 8 (2): 117-42. [PMID:12177684]
3. D'Aquila P, Monleon S, Borsini F, Brain P, Willner P. (1997)
Anti-anhedonic actions of the novel serotonergic agent flibanserin, a potential rapidly-acting antidepressant.
Eur. J. Pharmacol., 340 (2-3): 121-32. [PMID:9537806]
4. Invernizzi RW, Sacchetti G, Parini S, Acconcia S, Samanin R. (2003)
Flibanserin, a potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: role of 5-HT(1A) receptors.
Br. J. Pharmacol., 139 (7): 1281-8. [PMID:12890707]