imexon

Ligand id: 8273

Name: imexon

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 58.46
Molecular weight 111.04
XLogP -1.36
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-amino-1,3-diazabicyclo[3.1.0]hex-3-en-2-one
International Nonproprietary Names
INN number INN
4134 imexon
Synonyms
Amplimexon® (proposed trade name) | BM 06002 | BM-06002
Database Links
CAS Registry No. 59643-91-3
ChEMBL Ligand CHEMBL146428
DrugBank Ligand DB05003
PubChem CID 68791
Search Google for chemical match using the InChIKey BIXBBIPTYBJTRY-UHFFFAOYSA-N
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Wikipedia Imexon
Comments
Imexon is a cyclizised 2-cyanoaziridine compound being investigated as an antitumour agent [4-5]. 2-cyanoaziridine compounds bind thiols such as cysteine, depleting them and allowing the accumulation of reactive oxygen species. This effect activates antioxidant gene expression, signifying induction of an oxidative stress response [1] and leads to irreversible cell damage and apoptosis.