Synonyms: Amplimexon® (proposed trade name) | BM 06002 | BM-06002
Compound class:
Synthetic organic
Comment: Imexon is a cyclizised 2-cyanoaziridine compound being investigated as an antitumour agent [4-5]. 2-cyanoaziridine compounds bind thiols such as cysteine, depleting them and allowing the accumulation of reactive oxygen species. This effect activates antioxidant gene expression, signifying induction of an oxidative stress response [1] and leads to irreversible cell damage and apoptosis.
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
4-amino-1,3-diazabicyclo[3.1.0]hex-3-en-2-one |
International Nonproprietary Names | |
INN number | INN |
4134 | imexon |
Synonyms |
Amplimexon® (proposed trade name) | BM 06002 | BM-06002 |
Database Links | |
CAS Registry No. | 59643-91-3 |
ChEMBL Ligand | CHEMBL146428 |
DrugBank Ligand | DB05003 |
GtoPdb PubChem SID | 252166485 |
PubChem CID | 68791 |
Search Google for chemical match using the InChIKey | BIXBBIPTYBJTRY-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | BIXBBIPTYBJTRY |
Search PubMed clinical trials | imexon |
Search PubMed titles | imexon |
Search PubMed titles/abstracts | imexon |
UniChem Compound Search for chemical match using the InChIKey | BIXBBIPTYBJTRY-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | BIXBBIPTYBJTRY-UHFFFAOYSA-N |
Wikipedia | Imexon |