mifamurtide

Ligand id: 8274

Name: mifamurtide

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 25
Hydrogen bond donors 10
Rotatable bonds 59
Topological polar surface area 385.91
Molecular weight 1236.75
XLogP 9.69
No. Lipinski's rules broken 4

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (EMA (2009))
IUPAC Name
[3-[2-[[(2S)-2-[[(4R)-4-[[(2S)-2-[[(2R)-2-[(2R,3R,4R,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxypropanoyl]amino]propanoyl]amino]-5-amino-5-oxopentanoyl]amino]propanoyl]amino]ethoxy-hydroxyphosphoryl]oxy-2-hexadecanoyloxypropyl] hexadecanoate
International Nonproprietary Names
INN number INN
8744 mifamurtide
Synonyms
CGP 19835 | CGP-19835 | L-MTP-PE | liposomal muramyl tripeptide phosphatidyl ethanolamine | Mepact® | MLV 19835A
Database Links
CAS Registry No. 83461-56-7
PubChem CID 23725094
Search Google for chemical match using the InChIKey JMUHBNWAORSSBD-ZXSMYVEWSA-N
Search Google for chemicals with the same backbone JMUHBNWAORSSBD
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Search UniChem for chemical match using the InChIKey JMUHBNWAORSSBD-ZXSMYVEWSA-N
Search UniChem for chemicals with the same backbone JMUHBNWAORSSBD
Comments
Mifamurtide is a synthetic analogue of the bacterial cell wall component, muramyl dipeptide (MDP). MDP stimulates the immune system via activation of microbial pattern recognition receptors such as TLR4 and NOD2 [3,9].