ZD-7155

Ligand id: 8324

Name: ZD-7155

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 87.66
Molecular weight 438.22
XLogP 7.41
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
5,7-diethyl-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-3,4-dihydro-1,6-naphthyridin-2-one
Synonyms
ZD 7155 | ZD7155
Database Links
CAS Registry No. 151801-76-2 (source: Scifinder)
ChEMBL Ligand CHEMBL159096
PubChem CID 4673492
RCSB PDB Ligand ZD7
Search Google for chemical match using the InChIKey BFVNEYDCFJNLGN-UHFFFAOYSA-N
Search Google for chemicals with the same backbone BFVNEYDCFJNLGN
Search UniChem for chemical match using the InChIKey BFVNEYDCFJNLGN-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone BFVNEYDCFJNLGN
Comments
ZD-7155 is an orally active antagonist of the angiotensin II type 1 receptor. It is more potent and longer-acting than the prototype AT1 antagonist, losartan (in rats) [1].
ZD-7155 has been co-crystalised with a modified human AT1 receptor with PDB structure ID 4YAY, but the reference is yet to be published.