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Molecular properties generated using the CDK |
Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f]-[1, 2, 4] triazolo [4,3-a] [1, 4] diazepin-6-yl]-N-(4-hydroxyphenyl)-acetamide dehydrate |
International Nonproprietary Names ![]() |
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INN number | INN |
10407 | birabresib |
Synonyms ![]() |
MK-8628 | OTX-015 | OTX015 |
Comments |
OTX015 inhibits interaction between bromodomain and extra-terminal (BET) family of bromodomain-containing proteins (BRDs) BET domains and acetylated histone 4 (AcH4). It is an orally available novel BRD2/3/4 inhibitor with potent preclinical anti-tumour activity [1,4,6,10,12-13]. OTX015 is an analogue of (+)-JQ1. |
Database Links ![]() |
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CAS Registry No. | 202590-98-5 (source: WHO INN record) |
GtoPdb PubChem SID | 252166571 |
PubChem CID | 9936746 |
RCSB PDB Ligand | 6JE |
Search Google for chemical match using the InChIKey | GNMUEVRJHCWKTO-FQEVSTJZSA-N |
Search Google for chemicals with the same backbone | GNMUEVRJHCWKTO |
Search PubMed clinical trials | birabresib |
Search PubMed titles | birabresib |
Search PubMed titles/abstracts | birabresib |
Search UniChem for chemical match using the InChIKey | GNMUEVRJHCWKTO-FQEVSTJZSA-N |
Search UniChem for chemicals with the same backbone | GNMUEVRJHCWKTO |
OTX 015
Cat. No. 6181 |