Structure and Physico-chemical Properties
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Molecular properties generated using the CDK |
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Classification  |
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| Compound class | Synthetic organic |
| IUPAC Name |
| 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f]-[1, 2, 4] triazolo [4,3-a] [1, 4] diazepin-6-yl]-N-(4-hydroxyphenyl)-acetamide dehydrate |
| International Nonproprietary Names |
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| INN number | INN |
| 10407 | birabresib |
| Synonyms |
| MK-8628 | OTX-015 | OTX015 |
| Comments |
| OTX015 inhibits interaction between bromodomain and extra-terminal (BET) family of bromodomain-containing proteins (BRDs) BET domains and acetylated histone 4 (AcH4). It is an orally available novel BRD2/3/4 inhibitor with potent preclinical anti-tumour activity [1,4,6,10,12-13]. OTX015 is an analogue of (+)-JQ1. |
| Database Links |
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| CAS Registry No. | 202590-98-5 (source: WHO INN record) |
| GtoPdb PubChem SID | 252166571 |
| PubChem CID | 9936746 |
| RCSB PDB Ligand | 6JE |
| Search Google for chemical match using the InChIKey | GNMUEVRJHCWKTO-FQEVSTJZSA-N |
| Search Google for chemicals with the same backbone | GNMUEVRJHCWKTO |
| Search PubMed clinical trials | birabresib |
| Search PubMed titles | birabresib |
| Search PubMed titles/abstracts | birabresib |
| Search UniChem for chemical match using the InChIKey | GNMUEVRJHCWKTO-FQEVSTJZSA-N |
| Search UniChem for chemicals with the same backbone | GNMUEVRJHCWKTO |
Product suppliers
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Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please contact us.
✖
Sponsored products disclaimer
Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.
Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please contact us.
✖
OTX 015
Cat. No. 6181 |
