Ligand id: 8359

Name: birabresib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 120.64
Molecular weight 491.12
XLogP 5.16
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Bioactivity Comments
To date affinity data for OTX015 is only available from a meeting abstract [8], in which EC50 values for OTX015 binding to BRD2, BRD3, and BRD4 fall within the 10-19nM range. Biological in vitro and in vivo effects have been reported: for example, preclinical findings in B-cell tumor models [3] and in glioblastoma models [1].