AMG319

Ligand id: 8917

Name: AMG319

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 92.27
Molecular weight 385.15
XLogP 3.78
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[(1S)-1-(7-fluoro-2-pyridin-2-ylquinolin-3-yl)ethyl]-7H-purin-6-amine
Synonyms
AMG 319 | AMG-319
Database Links
CAS Registry No. 1608125-21-8 (source: PubChem)
PubChem CID 68947304
RCSB PDB Ligand 3VC
Search Google for chemical match using the InChIKey KWRYMZHCQIOOEB-LBPRGKRZSA-N
Search Google for chemicals with the same backbone KWRYMZHCQIOOEB
Search UniChem for chemical match using the InChIKey KWRYMZHCQIOOEB-LBPRGKRZSA-N
Search UniChem for chemicals with the same backbone KWRYMZHCQIOOEB
SynPHARM 83128 (in complex with phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
Comments
AMG319 is an inhibitor of phosphoinositide 3-kinase δ (PI3Kδ) inhibitor, with potential clinical anti-inflammatory utility [1].