sapelizumab

Ligand id: 9093

Name: sapelizumab

Classification
Compound class Antibody
International Nonproprietary Names
INN number INN
10065 sapelizumab
Synonyms
SA-237
SA237
Database Links
Specialist databases
IMGT/mAb-DB 586
Other databases
Search PubMed clinical trials sapelizumab
Search PubMed titles sapelizumab
Search PubMed titles/abstracts sapelizumab
Comments
Sapelizumab is an investigational humanized monoclonal antibody targeting the IL-6 receptor, with immunomodulatory potential. This antibody is an improved version of tocilizumab, with enhanced antigen-neutralizing ability and pharmacokinetics suitable for less frequent administration [1].
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. Peptide BLAST searches reveal identical matches between the heavy and light chain sequences as annotated in IMGT and SEQ IDs 26 and 29 respectively claimed in patent US8562991 [1]. This matches sapelizumab to the Fv4-M73 construct in the patent.