fremanezumab

Ligand id: 9208

Name: fremanezumab

Classification
Compound class Antibody
International Nonproprietary Names
INN number INN
10299 fremanezumab
Synonyms
LBR-101
PF-04427429
RN307
TEV-48125
Database Links
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Comments
Fremanezumab (TEV-48125) is an investigational humanised IgG2a monoclonal antibody targeting calcitonin gene-related peptide (CGRP) [3-4], a peptide known to play a role in causing migraines. TEV-48125 was originally formulated as an intravenous agent, but has been re-formulated to allow sub-cutaneous administration. Anti-CGRP antibodies are being developed as an alternative to CGRP receptor antagonists (such as telcagepant) which have already been shown to effectively reduce migraine headache and inhibit neurogenic vasodilatation in humans, and validated the CGRP/CGPR receptor as targets for the acute and preventive treatments of migraine. Anti-CGRP antibodies have the advantage of longer half-lives compared to small molecule antagonists and are expected to exhibit fewer toxicities attributed to off-target interactions, toxitities which have thwarted the development of CGRP receptor antagonists.
The original patent claiming anti-CGRP antibodies held by Rinat Neuroscience Corp. who originally developed TEV-48125 (as RN307) is WO2007054809 [5].