AM7499

Ligand id: 9257

Name: AM7499

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 75.99
Molecular weight 404.26
XLogP 3.99
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
butyl 2-[(6aR,9R,10aR)-1-hydroxy-9-(hydroxymethyl)-6,6-dimethyl-6H,6aH,7H,8H,9H,10H,10aH-benzo[c]isochromen-3-yl]-2-methylpropanoate
Synonyms
compound 3b [PMID: 27367336]
Database Links
Search Google for chemical match using the InChIKey OSVHLUXLWQLPIY-KBAYOESNSA-N
Search Google for chemicals with the same backbone OSVHLUXLWQLPIY
Comments
AM7499 is a non-selective cannabinoid receptor agonist [1]. It has been designed to be readily hydrolysed by plasma esterases (to shorten its duration of action; such compounds are being called 'controlled-deactivation cannabinoids') and to be less prone to deposition in bodily fat than existing classical cannabinoid agonists. This strategy has been adopted to produce cannabinoid agonists with improved drug-like qualities and potentially a more favourable safety profile.