Ligand id: 9257

Name: AM7499

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 75.99
Molecular weight 404.26
XLogP 3.99
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
AM7499 is functionally active at the cannabinoid receptors in cAMP accumulation assays; EC50 2.5nM vs. rat CB1 receptor, and 0.3nM vs human CB2 receptor [1]. The esterase hydrolysis products of AM7499 are inactive vs. both cannabinoid receptors.
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
CB2 receptor Mm Agonist Agonist 10.0 pKi - 1
pKi 10.0 (Ki 1x10-10 M) [1]
CB1 receptor Rn Agonist Agonist 8.6 pKi - 1
pKi 8.6 (Ki 2.4x10-9 M) [1]
CB2 receptor Hs Agonist Agonist 8.5 pKi - 1
pKi 8.5 (Ki 3.1x10-9 M) [1]