microtubule associated protein tau

Ligand id: 9275

Name: microtubule associated protein tau

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
MAPT microtubule associated protein tau Human microtubule associated protein tau isoform 1 microtubule-associated protein tau, MSTD, tau protein
Comments
The MAPT gene transcript undergoes complex, regulated alternative splicing. Different splice variants are expressed in different neurons and at different stages of neuronal maturation. The 757 amino acid isoform 1 contains three tau/MAP repeats which mediate tau interaction with tubulin (isoforms with four tau/MAP repeats are also reported).

MAPT gene polymorphisms are reported to predispose to neurodegenerative diseases including Alzheimer's disease (AD), Pick's disease [2-3,6] and frontotemporal dementia [4-5,9]. These types of conditions are known as tauopathies. The neurofibrillary tangles detected in AD brains are made up of pathologic paired helical filaments composed in large part of a truncated 100-amino-acid fragment of tau protein [8].

So far we have annotated two types of target relationships for tau protein:
1) aggregation antagonists/inhibitors (e.g. leucomethylthioninium)
2) imaging reagents for detection (e.g. flortaucipir (18F))