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|Compound class||Endogenous peptide in human, mouse or rat|
|The MAPT gene transcript undergoes complex, regulated alternative splicing. Different splice variants are expressed in different neurons and at different stages of neuronal maturation. The 757 amino acid isoform 1 contains three tau/MAP repeats which mediate tau interaction with tubulin (isoforms with four tau/MAP repeats are also reported).
MAPT gene polymorphisms are reported to predispose to neurodegenerative diseases including Alzheimer's disease (AD), Pick's disease [2-3,6] and frontotemporal dementia [4-5,9]. These types of conditions are known as tauopathies. The neurofibrillary tangles detected in AD brains are made up of pathologic paired helical filaments composed in large part of a truncated 100-amino-acid fragment of tau protein .
So far we have annotated two types of target relationships for tau protein:
1) aggregation antagonists/inhibitors (e.g. leucomethylthioninium)
2) imaging reagents for detection (e.g. flortaucipir (18F))
|GtoPdb PubChem SID||318164794|