mucosal addressin cell adhesion molecule 1

Ligand id: 9339

Name: mucosal addressin cell adhesion molecule 1

Abbreviated name: MAdCAM-1

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 Human mucosal addressin cell adhesion molecule 1 isoform a precursor -
Synonyms
addressin | MAdCAM1
Database Links
UniProtKB Q13477
Comments
MAdCAM-1 is an extracellular immunoglobulin-like peptide expressed on endothelial cells of intestinal lymphoid tissue [1-2], where it plays a role in role in gut immune surveillance. It is the ligand for homing receptors (e.g. α4β7 and α4β1 integrins, and L-selectin) on lymphocytes and it acts to direct leukocytes into mucosal and inflamed tissues. The α4β7/MAdCAM-1 interaction is gut-specific. MAdCAM-1 is being investigated as a drug target with potential for management of inflammatory bowel conditions.

The peptide details we provide are for the α isoform, which forms from the longest and predominant transcript. Soluble MAdCAM-1 can be detected in serum.