mucosal addressin cell adhesion molecule 1

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Ligands
mucosal addressin cell adhesion molecule 1 (Human)

Ligand id: 9339

Name: mucosal addressin cell adhesion molecule 1

Abbreviated name: MAdCAM-1

Species: Human

Classification
Compound class	Endogenous peptide in human, mouse or rat

Gene/Precursor

Gene symbol	Gene name	Species	Precursor protein name	Synonyms
MADCAM1	mucosal vascular addressin cell adhesion molecule 1	Human	mucosal addressin cell adhesion molecule 1 isoform a precursor	-

Synonyms
addressin
MAdCAM1

Synonyms

addressin

MAdCAM1

Database Links
UniProtKB	Q13477

Comments
MAdCAM-1 is an extracellular immunoglobulin-like peptide expressed on endothelial cells of intestinal lymphoid tissue [1-2], where it plays a role in role in gut immune surveillance. It is the ligand for homing receptors (e.g. α4β7 and α4β1 integrins, and L-selectin) on lymphocytes and it acts to direct leukocytes into mucosal and inflamed tissues. The α4β7/MAdCAM-1 interaction is gut-specific. MAdCAM-1 is being investigated as a drug target with potential for management of inflammatory bowel conditions. The peptide details we provide are for the α isoform, which forms from the longest and predominant transcript. Soluble MAdCAM-1 can be detected in serum.

Comments

MAdCAM-1 is an extracellular immunoglobulin-like peptide expressed on endothelial cells of intestinal lymphoid tissue [1-2], where it plays a role in role in gut immune surveillance. It is the ligand for homing receptors (e.g. α4β7 and α4β1 integrins, and L-selectin) on lymphocytes and it acts to direct leukocytes into mucosal and inflamed tissues. The α4β7/MAdCAM-1 interaction is gut-specific. MAdCAM-1 is being investigated as a drug target with potential for management of inflammatory bowel conditions.

The peptide details we provide are for the α isoform, which forms from the longest and predominant transcript. Soluble MAdCAM-1 can be detected in serum.