mucosal addressin cell adhesion molecule 1

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Ligands
mucosal addressin cell adhesion molecule 1 (Human)

GtoPdb Ligand ID: 9339

Abbreviated name: MAdCAM-1

Synonyms: addressin | MAdCAM1

Compound class: Endogenous peptide in human, mouse or rat

Comment: MAdCAM-1 is an extracellular immunoglobulin-like peptide expressed on endothelial cells of intestinal lymphoid tissue [5,7], where it plays a role in gut immune surveillance. It is the ligand for homing receptors (e.g. α4β7 and α4β1 integrins, and L-selectin) on lymphocytes and it acts to direct leukocytes into mucosal and inflamed tissues. The α4β7/MAdCAM-1 interaction is gut-specific. MAdCAM-1 is being investigated as a drug target with potential for management of inflammatory bowel conditions [1,3,6,9]. It has also been identified as a mechanistic target that regulates gut dysbiosis during immune checkpoint blockade cancer treatment [2,4].

The peptide details we provide are for the α isoform, which forms from the longest and predominant transcript. Soluble MAdCAM-1 can be detected in serum.

Species: Human

References
1. Biswas S, Bryant RV, Travis S. (2019) Interfering with leukocyte trafficking in Crohn's disease. Best Pract Res Clin Gastroenterol, 38-39: 101617. [PMID:31327399]
2. Chelvanambi M, Wargo JA. (2023) MAdCAM-1: a newly identified microbial 'gut check' for T cells. Trends in Immunology, Epub ahead of print. DOI: 10.1016/j.it.2023.06.007
3. Duijvestein M, D'Haens GR. (2019) Rational and clinical development of the anti-MAdCAM monoclonal antibody for the treatment of IBD. Expert Opin Biol Ther, 19 (4): 361-366. [PMID:30696342]
4. Fidelle M, Rauber C, Alves Costa Silva C, Tian AL, Lahmar I, de La Varende AM, Zhao L, Thelemaque C, Lebhar I, Messaoudene M et al.. (2023) A microbiota-modulated checkpoint directs immunosuppressive intestinal T cells into cancers. Science, 380 (6649): eabo2296. [PMID:37289890]
5. Ogawa H, Binion DG, Heidemann J, Theriot M, Fisher PJ, Johnson NA, Otterson MF, Rafiee P. (2005) Mechanisms of MAdCAM-1 gene expression in human intestinal microvascular endothelial cells. Am J Physiol, Cell Physiol, 288 (2): C272-81. [PMID:15483224]
6. Picardo S, Panaccione R. (2020) Anti-MADCAM therapy for ulcerative colitis. Expert Opin Biol Ther, 20 (4): 437-442. [PMID:31709847]
7. Streeter PR, Berg EL, Rouse BT, Bargatze RF, Butcher EC. (1988) A tissue-specific endothelial cell molecule involved in lymphocyte homing. Nature, 331 (6151): 41-6. [PMID:3340147]
8. Wang M, Kussrow AK, Ocana MF, Chabot JR, Lepsy CS, Bornhop DJ, O'Hara DM. (2017) Physiologically relevant binding affinity quantification of monoclonal antibody PF-00547659 to mucosal addressin cell adhesion molecule for in vitro in vivo correlation. Br J Pharmacol, 174 (1): 70-81. [PMID:27760281]
9. Zundler S, Wiendl M, Neurath MF. (2019) Anti-trafficking agents in the treatment of inflammatory bowel disease. Curr Opin Gastroenterol, 35 (6): 499-506. [PMID:31567498]

References

1. Biswas S, Bryant RV, Travis S. (2019)
Interfering with leukocyte trafficking in Crohn's disease.
Best Pract Res Clin Gastroenterol, 38-39: 101617. [PMID:31327399]

2. Chelvanambi M, Wargo JA. (2023)
MAdCAM-1: a newly identified microbial 'gut check' for T cells.
Trends in Immunology, Epub ahead of print. DOI: 10.1016/j.it.2023.06.007

3. Duijvestein M, D'Haens GR. (2019)
Rational and clinical development of the anti-MAdCAM monoclonal antibody for the treatment of IBD.
Expert Opin Biol Ther, 19 (4): 361-366. [PMID:30696342]

4. Fidelle M, Rauber C, Alves Costa Silva C, Tian AL, Lahmar I, de La Varende AM, Zhao L, Thelemaque C, Lebhar I, Messaoudene M et al.. (2023)
A microbiota-modulated checkpoint directs immunosuppressive intestinal T cells into cancers.
Science, 380 (6649): eabo2296. [PMID:37289890]

5. Ogawa H, Binion DG, Heidemann J, Theriot M, Fisher PJ, Johnson NA, Otterson MF, Rafiee P. (2005)
Mechanisms of MAdCAM-1 gene expression in human intestinal microvascular endothelial cells.
Am J Physiol, Cell Physiol, 288 (2): C272-81. [PMID:15483224]

6. Picardo S, Panaccione R. (2020)
Anti-MADCAM therapy for ulcerative colitis.
Expert Opin Biol Ther, 20 (4): 437-442. [PMID:31709847]

7. Streeter PR, Berg EL, Rouse BT, Bargatze RF, Butcher EC. (1988)
A tissue-specific endothelial cell molecule involved in lymphocyte homing.
Nature, 331 (6151): 41-6. [PMID:3340147]

8. Wang M, Kussrow AK, Ocana MF, Chabot JR, Lepsy CS, Bornhop DJ, O'Hara DM. (2017)
Physiologically relevant binding affinity quantification of monoclonal antibody PF-00547659 to mucosal addressin cell adhesion molecule for in vitro in vivo correlation.
Br J Pharmacol, 174 (1): 70-81. [PMID:27760281]

9. Zundler S, Wiendl M, Neurath MF. (2019)
Anti-trafficking agents in the treatment of inflammatory bowel disease.
Curr Opin Gastroenterol, 35 (6): 499-506. [PMID:31567498]