atovaquone

Ligand id: 9695

Name: atovaquone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 54.37
Molecular weight 366.1
XLogP 7.28
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Ligand families/groups Antimalarial ligands
Approved drug? Yes (FDA (1992))
IUPAC Name
trans-2-[4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione
International Nonproprietary Names
INN number INN
6914 atovaquone
Synonyms
Mepron®
Comments
Atovaquone is a synthetic hydroxynaphthoquinone with broad-spectrum antiprotozoal activity. It is an antimalarial drug and used in combination with proguanil.
Note that we have drawn the molecule as specified by the INN record and ChEMBL entry listed on this summary page. The structure for PubChem CID 74989 shows a different tautomer, with InChi Key BSJMWHQBCZFXBR-UHFFFAOYSA-N.
Database Links
CAS Registry No. 95233-18-4 (source: Scifinder)
ChEMBL Ligand CHEMBL1450
DrugBank Ligand DB01117
GtoPdb PubChem SID 348353654
RCSB PDB Ligand AOQ
Search Google for chemical match using the InChIKey KUCQYCKVKVOKAY-CTYIDZIISA-N
Search Google for chemicals with the same backbone KUCQYCKVKVOKAY
Search PubMed clinical trials atovaquone
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Search UniChem for chemical match using the InChIKey KUCQYCKVKVOKAY-CTYIDZIISA-N
Search UniChem for chemicals with the same backbone KUCQYCKVKVOKAY
Wikipedia Atovaquone