AZD0156

Ligand id: 9942

Name: AZD0156

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 71.03
Molecular weight 461.24
XLogP 2.71
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
8-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-3-methyl-1-(oxan-4-yl)imidazo[4,5-c]quinolin-2-one
Synonyms
compound 64 [PMID: 29683659]
Comments
AZD0156 is a potent and selective inhibitor of ATM serine/threonine kinase from AstraZeneca that is being developed for anti-cancer potential [1]. It potentiates the efficacy of irinotecan and olaparib in disease relevant mouse models and is currently undergoing clinical evaluation.
Database Links
GtoPdb PubChem SID 363894236
PubChem CID 118502708
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Search UniChem for chemicals with the same backbone AOTRIQLYUAFVSC