Synonyms: LY-3214996 | LY3214996
Compound class:
Synthetic organic
Comment: LY3214996 is an ERK1/2 inhibitor that is in early stage clinical development for the potential treatment of advanced non-hematological tumours, in particular for malignancies carrying activating MAPK pathway alterations, and which are refractory to RAF and MEK inhibitors.
(Note: ERK1= MAPK3, ERK2= MAPK1). The chemical structure of LY3214996 matches that for the INN compound temuterkib that was surfaced in WHO Proposed list 125 in July 2021. |
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
6,6-dimethyl-2-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-5-(2-morpholin-4-ylethyl)thieno[2,3-c]pyrrol-4-one |
International Nonproprietary Names | |
INN number | INN |
11680 | temuterkib |
Synonyms |
LY-3214996 | LY3214996 |
Database Links | |
CAS Registry No. | 1951483-29-6 (source: WHO INN record) |
GtoPdb PubChem SID | 374883862 |
PubChem CID | 121408882 |
RCSB PDB Ligand | KE8 |
Search Google for chemical match using the InChIKey | JNPRPMBJODOFEC-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | JNPRPMBJODOFEC |
Search PubMed clinical trials | temuterkib |
Search PubMed titles | temuterkib |
Search PubMed titles/abstracts | temuterkib |
UniChem Compound Search for chemical match using the InChIKey | JNPRPMBJODOFEC-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | JNPRPMBJODOFEC-UHFFFAOYSA-N |