Synonyms: ONO 7579 | ONO7579
Compound class:
Synthetic organic
Comment: Highly potent and selective pan-tropomyosin receptor kinase family (neurotrophic tyrosine receptor kinase; TRKA, TRKB, TRKC) inhibitor.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
The or a lly a va ila ble and nove l s ma ll mole c ule, ONO-7579 (N-{2-[4-(2-amino-5-chlor opyr idin-3-yl)phenoxy]pyr imidin-5-yl}-N'-[2-( methanesulf onyl)-5-(trifluoromethyl)phenyl]urea), is a highly potent and selective pan-tropomyosin receptor kinase (TRK) inhibit orNeurotrophic tyrosine receptor kinase (NTRK) 1, NTRK2, and NTRK3 genes encode tropomyosin receptor kinase (TRK) A, TRKB, and TRKC, respectively, which are members of the TRK family of receptor tyrosine kinases. |
Selectivity at catalytic receptors | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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