methenamine   Click here for help

GtoPdb Ligand ID: 10913

Synonyms: Hiprex® | Mandelamine® | Urex®
Approved drug
methenamine is an approved drug (FDA (1967), UK (1989))
Compound class: Synthetic organic
Comment: Methenamine is a heterocyclic organic compound. It is metabolised to formaldehyde, which acts as a nonspecific bactericidal agent. Methenamine is administered as the hippuric acid salt, methenamine hippurate (PubChem CID 21945).
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 12.96
Molecular weight 140.11
XLogP -0.19
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES C1N2CN3CN1CN(C2)C3
Isomeric SMILES C1N2CN3CN1CN(C2)C3
InChI InChI=1S/C6H12N4/c1-7-2-9-4-8(1)5-10(3-7)6-9/h1-6H2
InChI Key VKYKSIONXSXAKP-UHFFFAOYSA-N
Bioactivity Comments
We have been unable to find quantitative data for the antibacterial activity of this drug. At mammalian targets, 10 μM methenamine hippurate inhibits sodium fluorescein uptake via hamster OATP1B1 in transfected CHO cells by 93% [1].