SMT022357   Click here for help

GtoPdb Ligand ID: 11111

Synonyms: (±)-4 | (±)-SMT022357 | compound 4 [Babbs et al., 2020]
Compound class: Synthetic organic
Comment: SMT022357 is a second-generation, oral utrophin modulator. It was developed from the same chemical series as clinically evaluated ezutromid, but with a new chemotype [1]. SMT022357 has improved physicochemical and ADME properties compared to ezutromid, and has demonstrated efficacy in dystrophin-deficient mdx mice [1-2]. The molecular target of SMT022357 has not been reported, but may be the aryl hydrocarbon receptor, in common with ezutromid.

Clinical rationale: Up-regulation of utrophin (UTRN; P46939) as being investigated as a disease-modifying approach for Duchenne muscular dystrophy (DMD). In the mdx mouse DMD model, increased levels of utrophin effectively acts as a substitute for the dystrophin (DMD; P11532) that is missing in DMD [3].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 62.14
Molecular weight 369.07
XLogP 4.14
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCP(=O)(c1ccc2c(c1)nc(o2)c1cccc(c1)C(F)(F)F)OC
Isomeric SMILES CCP(=O)(c1ccc2c(c1)nc(o2)c1cccc(c1)C(F)(F)F)OC
InChI InChI=1S/C17H15F3NO3P/c1-3-25(22,23-2)13-7-8-15-14(10-13)21-16(24-15)11-5-4-6-12(9-11)17(18,19)20/h4-10H,3H2,1-2H3
InChI Key GIJPBJLOHMBSSM-UHFFFAOYSA-N
Bioactivity Comments
We show the structure of the racemate in this entry. Stereoselective synthesis showed that there was no significant difference in the activity or efficacy between the two enantiomers in preclinical studies, and the activities of the enantiomers was comparable to the racemic mixture [1]. SMT022357 increases the utrophin protein level in vitro and in vivo, and reduces skeletal, respiratory, and cardiac muscle pathology in the mdx mouse [2]. The two enantiomers had similar PK profiles in the mdx mouse, but this was not the case in rats. SMT022357 was found to be hepatotoxic in rats and its therapeutic window was considered to be too narrow to support clinical development.