Synonyms: compound 1 [WO2012024404A1]
Compound class:
Synthetic organic
Comment: The chemical structure that was submitted to the WHO for the INN dalosirvat (in which it is defined as a 'sirtuin activator'), is a match with compound 1 as claimed in Wintherix's patent as a Wnt pathway activator [1]. Speculatively dalosirvat may be Samumed's SM04554, which is a clinical lead being investigated as a topical therapy to promote hair follicle development and hair regrowth in individuals suffering from androgenetic alopecia (Phase 2/3 NCT03742518). As of August 2020, there has been no formal name>structure disclosure for SM04554.
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Bioactivity Comments |
Dalosirvat (compound 1) activates Wnt pathway signalling with an IC50 <30 nM, as determined in a luciferase reporter assay in SW480 cells, under the control of a Wnt-responsive promoter [1]. |