Synonyms: SCO267
Compound class:
Synthetic organic
Comment: SCO-267 is a GPR40 full agonist [1]. Agonist activation of GPR40 (which stimulates secretion of insulin and incretin) is considered to be an attractive mechanism for promoting glycemic control in the treatment of type 2 diabetes mellitus.
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Bioactivity Comments |
In diabetic rats SCO-267 effectively stimulates GPR40-dependent insulin and GLP-1 release and ameliorates glucose tolerance. |