Synonyms: BI-853520 | BI853520 | IN10018
Compound class:
Synthetic organic
Comment: We mapped the structure for the INN ifebemtinib via PubChem to the research code BI-853520. BI-853520 is a selective, ATP-competitive inhibitor of focal adhesion kinase (FAK), that has anti-tumour effects in preclinical [3,5] and early clinical studies [1-2]. FAK inhibitors enhance effector T cell infiltration into the tumour microenvironment [4].
|
|
Bioactivity Comments |
BI 853520 inhibits FAK autophosphorylation in PC-3 prostate carcinoma cells with an IC50 of 1 nM [3]. |