neuroligin 1

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Ligands
neuroligin 1 (Human)

GtoPdb Ligand ID: 12818

Compound class: Endogenous peptide in human, mouse or rat

Comment: Neuroligin 1 is a postsynaptic, single-pass neuronal cell surface protein. It interacts with presynaptically expressed neurexins to stabilise synapses.

Species: Human

Summary
Biological activity
References

Bioactivity Comments
Neuroligin-1 has been identified as one of a set of five ligands whose activity at their receptors contribute to cell-cell communication during human astrocyte development [2]. The other four ligands are TGFβ2, thymic stromal lymphopoietin (TSLP), Dickkopf 1 (DKK1) and BMP-4. The black widow spider venom α-latrotoxin is thought to disrupt neuroligin/neurexin binding across synapses, and to contribute to toxin-induced neurotransmitter release [1].

Bioactivity Comments

Neuroligin-1 has been identified as one of a set of five ligands whose activity at their receptors contribute to cell-cell communication during human astrocyte development [2]. The other four ligands are TGFβ2, thymic stromal lymphopoietin (TSLP), Dickkopf 1 (DKK1) and BMP-4. The black widow spider venom α-latrotoxin is thought to disrupt neuroligin/neurexin binding across synapses, and to contribute to toxin-induced neurotransmitter release [1].