Synonyms: 14,539 RP | Solosec® | SYM-1219
secnidazole is an approved drug (FDA (2017))
Compound class:
Synthetic organic
Comment: Secnidazole is a broad-spectrum nitroimidazole antimicrobial compound that exhibits antiprotozoal and antibacterial (Gram-positive and Gram-negative) activities.
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Bioactivity Comments |
A study of bacterial spp. associated with bacterial vaginosis has shown that secnidazole has good activity against both Gram-positive and Gram-negative pathogens [2]. The minimal inhibitory concentration (MIC) for antibacterial activity against clinical isolates of the anaerobic Gram-negative Bacteroides fragilis is in the range of 0.09-0.93 μg/ml [1]. In vitro testing of clinical strains of Trichomonas has estimated a MIC of 0.7 μg/ml and a minimal trichomonacidal concentration (MTC) of 0.63 μg/ml [3]. |